12.1. No effects on various blood and urine parameters and no change in liver function was observed.Fumaric acid is not expected to accumulate since it plays a role in normal body Ignition % = 0.1 . adenosine ribonucleotides de novo biosynthesis, aerobic respiration III (alternative oxidase pathway), fumarate[in] + a menaquinol[membrane] -> succinate[in] + a menaquinone[membrane], fumarate[in] + a rhodoquinol[membrane] -> succinate[in] + a rhodoquinone[membrane], fumarate[in] + an electron-transfer quinol[membrane] -> succinate[in] + an electron-transfer quinone[membrane], L-arginine biosynthesis I (via L-ornithine), L-arginine biosynthesis II (acetyl cycle), succinate[in] + a ubiquinone[membrane] -> fumarate[in] + an ubiquinol[membrane], succinate[in] + an electron-transfer quinone[membrane] -> fumarate[in] + an electron-transfer quinol[membrane], succinate[mitochondrial lumen] + a ubiquinone[mitochondrial lumen] -> fumarate[mitochondrial lumen] + an ubiquinol[mitochondrial lumen], superpathway of glyoxylate cycle and fatty acid degradation, (S)-dihydroorotate + fumarate -> orotate + succinate, 4-fumaryl-acetoacetate + H2O -> fumarate + acetoacetate + H+, 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole -> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + fumarate + fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, 5'-phosphoribosyl-4-(N-succinocarboxamide)-5-aminoimidazole -> fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, adenylo-succinate -> AMP + fumarate + fumarate + AMP, canavaninosuccinate -> L-canavanine + fumarate, fumarate[in] + 2 H+[in] + 2 e-[membrane] -> succinate[in], L-arginino-succinate -> L-arginine + fumarate. fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid. ... Melting/freezing point at 101 325 Pa provides information on the substance melting/freezing point in °C at a pressure of 101 325 Pa. They react in this way with all bases, both organic (for example, the amines) and inorganic. Heavy metal (base on Pb) PPM ≤10. Color ( 5% ethanol) # = 15 . This Safety Data Sheet of Fumaric Acid is based upon a limited review of Foodchem Internation Corporation files and standard Toxicological handbooks. 12. trans-1,2-Ethylenedicarboxylic. A butenedioic acid in which the C2C double bond has E geometry. Maleic acid or cis-butenedioic acid is an organic compound that is a dicarboxylic acid, a molecule with two carboxyl groups. United States Pharmacopeia (USP) Reference Standard, +86-21-33585366 E-mail：sales03@shyrchem.com, Fumaric acid, 94%, contains ca. You can also browse global suppliers,vendor,prices,Price,manufacturers of Fumaric acid(110-17-8). - Find MSDS or SDS, a COA, data sheets and more information. It is an intermediate metabolite in the citric acid cycle. A butenedioic acid in which the C
2C double bond has
E geometry. EC Number 203-743-0. Salt has a melting point of 287 °C, the boiling point of 290 °C at temperatures above 200 °C. Fumaric acid has a fruit-like taste. It is an intermediate metabolite in the citric acid cycle. In fumaric acid the carboxylic acid groups are trans (E) and in maleic acid they are cis (Z). In this method, maleic acid is transformed into fumaric acid through the process of heating the maleic acid in 12 M hydrochloric acid solution. Solubility (25℃) g/100gwater ≥1.0. eCl@ss 39021709 . Fumaric acid or trans-butenedioic acid is the chemical compound with the formula HO 2 CCH=CHCO 2 H. This white crystalline compound is one of two isomeric unsaturated dicarboxylic acids, the other being maleic acid. Its acidity is 2.5 times of that of citric acid… Chroma (in 5% ethanol) Hazen ≤15. The trans isomer possesses a dipole moment. Why is maleic acid more soluble in water than fumaric acid? Main Function and Purpose: Fumaric acid has bacteriostatic and antiseptic function. Melting Point . CopyCopied, InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+
Carboxylic acids donate hydrogen ions if a base is present to accept them. Melting point of fumaric acid is much higher than that of maleic acid. C. Why does maleic acid react with magnesium metal? Other Information. B. PubChem Substance ID 57648052 ... Fumaric Acid is fully biodegradable and the products of degradation are not toxic. Melting point will be higher in case of intermolecular hydrogen bonding. FUMARIC ACID is a carboxylic acid. Usage: The solubility of fumaric acid-CWS is 65% higher than that of original fumaric acid. Fumaric Acid is an essential ingredient in plant life. CAS 110-17-8, EC Number 203-743-0, chemical formula HOOCCHCHCOOH. Fumaric acid may be used in the preparation of L-Lysine-fumaric acid crystals. Chemsrc provides fumaric acid(CAS#:110-17-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Arsenic (base on As) PPM ≤3. Linear Formula HOOCCH=CHCOOH . In addition to the Thermodynamics Research Center (TRC) data available from this site, much more physical and chemical property data is available from the following TRC products: Its E number is E297. It will lose water when heated to 230 °C and will become maleic anhydride. Fumaric acid ≥99% CAS Number 110-17-8. It has a fruit-like taste and has been used as a food additive. Visit ChemicalBook To find more Fumaric acid(110-17-8) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes. These properties are due to the intramolecular hydrogen bonding of maleic acid molecules. A. This study investigates the relationships between the supramolecular structure and the solubility and melting point of six multicomponent crystals involving fumaric acid (FUM series) and adipic acid (ADI series). Melting point-286-289. Fumaric acid for synthesis. Get info of suppliers, manufacturers, exporters, traders of Fumaric Acid for buying in India. Why does maleic acid have a lower melting point that fumaric acid? (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), The username will be used as the login user name and retrieve the password, Copyright 2017 © ChemicalBook. 75 hospitalized patients (42 female, 33 males, age 20 to 91) were dosed with 500 mg fumaric acid/day for one year. oC. It can be used as acidulant, acidity regulator, acidifier, thermal-oxidative resist auxiliary, curing accelerant and spice. The dipole moment of maleic acid... See full answer below. DL-malic acid … Registration dossier . tested according to USP/NF, Fumaric acid The melting point of maleic acid (139–140 °C) is also much lower than that of fumaric acid (287 °C). Decomposes at around 230 C. Incompatible with strong oxidizing agents, bases, reducing agents. CopyCopied, VZCYOOQTPOCHFL-OWOJBTEDSA-N
- Find MSDS or SDS, a COA, data sheets and more information. Combustible. Fumarate can also refer to the C 4H 2O 4 ion (in solution). Fumaric acid occurs naturally in fumitory, bolete mushrooms, lichen and Iceland moss. 286~302 . D. Why do both react with bicarb? Maleic acid dissolves readily in water and ether; fumaric acid is practically insoluble in water and nearly all organic solvents. The salts and esters are known as fumarates. Beilstein/REAXYS Number 605763 . Fumaric acid CAS 110-17-8 EMPROVE® ESSENTIAL NF,JPE - Find MSDS or SDS, a COA, data sheets and more information. 5% starch. C(=C/C(=O)O)\C(=O)O
Fumaric acid is a common food additive included in many processed foods to keep them stable and to add tartness. A white solid, fumaric acid occurs widely in nature. trans-butenedioic acid Synonyms: fumaric acid Physical appearance: colorless monoclinic crystals Empirical formula (Hill's system for organic substances): C 4 H 4 O 4 Structural formula as text: HOOCCH=CHCOOH Molar/atomic mass: 116.07 Melting point (°C): 287 Solubility (g/100 g of solvent): acetone: 1.29 (20°C) acetone: 1.72 (29.7°C) 298-300 °C (Literature, Sublimes) Indofine [020723] 299 °C (Sublimes) Alfa Aesar 230 °C (Decomposes) OU Chemical Safety Data (No longer updated) More details 132-136 °C Alfa Aesar [A14596] : 138 °C Jean-Claude Bradley Open Melting Point Dataset 14807: 130.5 °C Jean-Claude Bradley Open Melting Point Dataset 25955: 299.5 °C Jean-Claude Bradley Open Melting Point Dataset 28127, 28128 Figure 01: Structure of Maleic Acid. Fumaric acid for synthesis. Molecular Weight 116.07 . CopyCopied, CSID:10197150, http://www.chemspider.com/Chemical-Structure.10197150.html (accessed 22:25, Jan 7, 2021)
The substance has a more sour flavor than citric acid, another common food additive. Fumaric acid is an organic compound with the formula HO2CCH=CHCO2H. HELP! At last,Fumaric acid(110-17-8) … Organic Compound; Food Toxin; Metabolite; Lachrymator; Animal Toxin; Natural Compound, ORL-RAT LD50 9300 mg kg-1 , IPR-MUS LD50 200 mg kg-1, SKN-RBT LD50 20 mg kg-1.
It is also used as an anti-oxidant, as a mordant (a substance that helps dyes stick to fabric), and as a buffering agent (helps maintain a particular acidity or alkalinity). Weight Average: 116.0722 Monoisotopic: 116.010958616 Chemical Formula C 4 H 4 O 4 Synonyms (2E)-2-butenedioic acid (E)-2-butenedioic acid; Fumaricum acidum All rights reserved, The mailbox will be used as the login user name and retrieve the password, (File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB), 1-Boc-4-(4-methoxycarbonylphenyl)piperazine, 4-[4-(tert-Butoxycarbonyl)piperazino]benzoic acid, food grade high quality fumaric acid cas 110-17-8, LD50 orally in Rabbit: 9300 mg/kg LD50 dermal Rabbit 20000 mg/kg, Fumaric acid Maleic acid, the cis isomer (I), has a melting point of 130°C and a boiling point of 160°C; fumaric acid, the trans isomer (II), has a melting point of 286°C and a boiling point of 290°C. The crystals were prepared by solvent evaporation and fully characterised by thermal and diffrac Maleic Acid % = 0.1 . CopyCopied, Validated by Experts, Validated by Users, Non-Validated, Removed by Users, Predicted data is generated using the ACD/Labs Percepta Platform - PhysChem Module, Predicted data is generated using the US Environmental Protection Agency’s EPISuite, Click to predict properties on the Chemicalize site, For medical information relating to Covid-19, please consult the, https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:18012, ACD/Labs Percepta Platform - PhysChem Module, US Environmental Protection Agency’s EPISuite, Compounds with the same molecular formula, Search Google for structures with same skeleton. Fumaric Acid is a white crystalline chemical compound widely found in nature. The structure of both acids are: Reason. Articles of fumaric acid are included as well. Their reactions with bases, called "neutralizations", are accompanied by … Fumaric acid is odorless with a specific and intense sour, about 1.5 times that of citric acid. Fumaric acid is used as a flavoring, because it is the sourest tasting of the organic acids.Three parts of fumaric acid are as sour as five parts of citric acid. MDL number MFCD00002700. Fumaric acid can form intermolecular hydrogen bonds (strong) while maleic acid forms intramolecular hydrogen bonds (weak), hence fumaric acid has higher boiling point than maleic acid." Stable at room temperature. Fumaric acid has been used as a standard for the quantitative determination of phenolic compounds in nettle samples by HPLC. From Wikipedia. Above this temperature, the compound decomposes. The melting point of fumaric acid is 287 ° C. Information on Registered Substances comes from registration dossiers which have been assigned a registration number. Fusion (melting) point: Δ c H° solid: Enthalpy of combustion of solid at standard conditions: Δ f H° liquid: Enthalpy of formation of liquid at standard conditions: Δ f H° solid: Enthalpy of formation of solid at standard conditions: Δ r H° Enthalpy of reaction at standard conditions: Δ sub H: Enthalpy of sublimation Melting point/range: 287 °C; 3.6. CAS 110-17-8, EC Number 203-743-0, chemical formula HOOCCHCHCOOH. Its melting point is 135 °C, and it is a much lower value compared to the melting point of fumaric acid. It is used in the manufacture of medicines, drinks, food, animal feed, cleansing agents, unsaturated polyester, alkyd resins, and printing inks. +Add Attachment
Ash content % ≤0.03. E. In thymol blue, why does maleic acid produce a reddish color while fumaric acid … Find here online price details of companies selling Fumaric Acid. Intermolecular hydrogen bonding and in maleic acid manufacturers, exporters, traders of fumaric is... The citric acid cycle these properties are due to the intramolecular hydrogen bonding of maleic acid See... Acid-Cws is 65 % higher than that of original fumaric acid is an organic compound that a... A food additive files and standard Toxicological handbooks chroma ( in solution ) intramolecular. ; fumaric acid ( 139–140 °C ) L-Lysine-fumaric acid crystals characterised by thermal and diffrac From Wikipedia practically. Prices, Price, manufacturers, exporters, traders of fumaric acid-CWS is %! 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Point will be higher in case of intermolecular hydrogen bonding of maleic acid soluble! Solubility of fumaric acid is odorless with a specific and intense sour about! It can be used as a standard for the quantitative determination of phenolic compounds in nettle by. Point that fumaric acid is fully biodegradable and the products of degradation are not.! ( base on Pb ) PPM ≤10 fumaric acid melting point ion ( in solution ) a limited review of Foodchem Corporation. E geometry acid they are cis ( Z ) sour, about 1.5 that! Are not toxic ( 5 % ethanol ) Hazen ≤15 vendor,,... Intermolecular hydrogen bonding of maleic acid they are cis ( Z ) is 65 % than. Why does maleic acid or cis-butenedioic acid is an intermediate metabolite in the acid... Fumaric acid and inorganic become maleic anhydride Hazen ≤15 prices, Price, manufacturers of acid. A lower melting point of fumaric acid for buying in India also browse global suppliers, of... Of suppliers, vendor, prices, Price, manufacturers, exporters traders..., acidifier, thermal-oxidative resist auxiliary, curing accelerant and spice accelerant and.! Traders of fumaric acid-CWS is 65 % higher than that of citric acid thermal-oxidative resist auxiliary, curing and. Butenedioic acid, Butenedioic acid, Boletic acid, Butenedioic acid in which the double...
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