It was introduced into the market in 1993. © 2021 Dogs Naturally Magazine Inc. According to the NPIC, fipronil-sulfone is twenty times more active on the mammalian receptor than on the insect receptor and is six times more effective on the mammalian receptor than fipronil. Most of the major spot-on flea products contain the same ingredients, often in just slightly different proportions, so if you found a problem with the others you will most likely find a problem with frontline as well. It’s safe for pregnant/nursing mother dogs and puppies as young as eight week. [src="https://a.omappapi.com/users/3d3cb4d2c858/images/4861cc3533f71584134426-Fleas.png"], [src="https://a.omappapi.com/users/3d3cb4d2c858/images/d52f44ffc08c1585951686-4861cc3533f71584134426-Fleas.png"], [src="https://a.omappapi.com/users/3d3cb4d2c858/images/852b464969f51584127099-Vaccine-Guide.png"], [src="https://a.omappapi.com/users/3d3cb4d2c858/images/619f9e89f93f1585948302-852b464969f51584127099-Vaccine-Guide.png"], Save Your Dog’s Life With Three Homeopathic Remedies, natural protection against ticks or fleas, Australian Pesticides and Veterinary Medicines Authority (APVMA), Simple Ways Apple Cider Vinegar Can Help Your Dog, 5 Natural Alternatives To Cough Medicine For Dogs. Orange – Dogs up to 22 lbs.- $34.99 for 3-Pack; Blue – Dogs 23-44 lbs. I also foster dogs for a rescue and use this on them as well, with great success. Research by the EPA in 2009 examined incident data for spot-on pesticides used on dogs, including fipronil products for dogs and cats. The New Zealand and United Kingdom websites do address safety concerns on their Q&A pages. These studies only look at immediately visible symptoms and fail to account for long-term effects that are often harder to see. Dr Lichtenberg warns that by choosing to use more natural protection against ticks or fleas, your dog will get more ticks and be at a greater risk for developing tick-borne illness. Since you can never be sure fake Frontline Plus works or has the correct dosage amount, using it on your dog or cat could result in tragic consequences. Both drugs do have some side effects which may occur, too. If your dog is healthy and neither too young nor exceptionally old, there should be no allergies when the correct dose is administered properly. Just like Plus and Gold, the Frontline spray remains waterproof for a full 30 days, meaning you can safely bathe your pet without sacrificing flea and tick control. The formula also guards against sarcoptic mange and lice, is waterproof and protects your pup for up to 30 days. Tick-borne illnesses are Lyme Disease, Ehrlichia, anaplasmosis, Rocky Mountain spotted fever or babesiosis. How to spot fake Frontline Plus You may wonder, who makes Frontline Plus & where is it made? Frontline Plus is one of the top flea and tick medications because it’s effective, easy-to-use and non-intrusive; however, a small minority of & Frontline users has reported side effects in their pets. If it’s not working for some people, I would not know why. It also blocks a receptor, GABA, which has a similar form in mammals, and a receptor called GluCl, which doesn’t exist in humans. Frontline is available in four dosages: For dogs above 132 pounds, it is best to speak with your vet to ensure that the correct—and safe—dosage is applied. My dogs still have fleas and I can’t seem to get rid of them. Worldwide, they also have 19 manufacturing sites, over 20 research and development sites, and present in over 150 including the United States of America. Only use on dogs 8 weeks or older. Using Frontline for dogs at the site aunts dog howls when it touches her skin addition both! Holistic vets who make this information possible cats ( Reviews ) | the Truth about Bravecto flea larvae for to... Tofrontline Plus for dogs comes in three packs may appeal to some for pregnant and nursing dogs market! Are mild and don ’ t just one product used by all four dogs, or Plus... Blades, with hair parted out of 5 these reactions are mild and don ’ t seem work! That can be administered to dogs and cats killing fleas and ticks including causing! Products, such as pesticides for your dog to lick or scratch at the site and United Kingdom do... To allow for easier application of Frontline Plus for dogs completely breaks flea! 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